Get Current topics in cellular regulation. Vol. 25 PDF

By Bernard L. Horecker, Earl R. Stadtman

ISBN-10: 0121528251

ISBN-13: 9780121528256

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This type of analysis may be extended to any branched system no matter how complex the overall system. An example of sensitive regulation at a branch point may be provided by the pathways of fatty acid utilization and oxidation in tissues. An increase in the extracellular long-chain fatty acid concentration results in many mammalian tissues in an increase in the rate of fatty acid oxidation. This is considered to be important in providing an alternative fuel for the tissue when the carbohydrate stores of the body are being depleted.

A Ί the overall communication is degenerate and the net sensitivity is the 32 B. CRABTREE AND E. A. NEWSHOLME TABLE I SENSITIVITIES O F ELEMENTARY C O M M U N I C A T I O N S 0 Elementary communication Effector, X, Effector, X,- Sensitivity , forward process r reverse process rx(=dv/dX-X/v) rx(=dV/dX-X/v) Forward process action net rate of re- R Reverse process tion net rate ofreac- -(R-l) Rate of forward reaction (]) of substrate cycle rnet flux Rate of reverse reaction of substrate cycle >net flux U + c/j) -c/j Comments** r c(x) = r (x) — rm(x); derived in this article.

ATP » 49 METABOLIC CONTROL It also provides an example of the treatment of external effectors which are in mutual communication (Section III,D). V. Regulatory Analysis of Branched Systems In Section II it was shown that branched systems could be expressed as a set of"quasi-linear" fluxes and it was stated that these could be treated, at least for the analysis of control, as if they were linear. The following is a simple example of how this can be done. (Ja) A/f(|uB^< ,(Jb) In this system there are three fluxes, / , / a , a n d / b , such t h a t / = (/ a + / b ) .

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Current topics in cellular regulation. Vol. 25 by Bernard L. Horecker, Earl R. Stadtman


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