By Bernard Leonard Horecker; Earl Reece Stadtman
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Additional info for Current topics in cellular regulation. Vol.11 : 1976
Stetten and Goldsmith (150) also found 1,3-diphosphoglycerate to function similarly as a phosphate donor for this enzyme. Special importance may be attached to the recent discovery that carbamyl phosphate, a substance which is formed readily in liver as a substrate for urea synthesis, is also active as a phos phate donor; and particularly significant is the fact that the pH optimum for carbamyl phosphate transfer is sufficiently close to the physiological to warrant serious consideration of carbamyl P as a physiological source of phosphate for glucose-6-P formation.
21) procured specimens of human liver by needle biopsy and obtained low but measurable activity which, like glucokinase of the rat, was increased on refeeding a carbohydrate-rich diet and decreased on a carbohydrate low diet. Two untreated diabetic subjects were studied. One was a severe juvenile diabetic with ketosis; and the second was an elderly maturity-onset diabetic. Both originally had very low liver glucokinase, which increased markedly after either 8 days of insulin treatment of the first subject or 35 days of Tolbutamide REGULATION OF GLUCOKINASE I N LIVER 29 treatment of the second subject.
C, Adv. Gerontol. Res. 4, 1-23 (1972). Adelman, R. C, Fed. Proc, Fed. Am. Soc. Exp. Biol. 34, 179-182 (1975). Adelman, R. C, and Freeman, C, Endocrinology 90, 1551-1560 (1972). Adelman, R. C, J. Biol. Chem. 245, 1032-1035 (1970). , Nature (London) 235, 137-140 (1972). Anderson, J. , and Tyrrell, J. , Gastroenterology 65, 69-76 (1973). Baldwin, R. , Adv. Cancer Res. 18,1-75 (1973). , Geddes, E. , Cancer Res. 33, 249-255 (1973). 9. Ballard, F. , Comp. Biochem. Physiol. 14, 437-443 (1965). 10. Ballard, F.
Current topics in cellular regulation. Vol.11 : 1976 by Bernard Leonard Horecker; Earl Reece Stadtman