Download PDF by Evdokia Anagnostou: Clinician’s Manual on Autism Spectrum Disorder

By Evdokia Anagnostou

ISBN-10: 3319030558

ISBN-13: 9783319030555

ISBN-10: 3319030566

ISBN-13: 9783319030562

This concise, but useful instruction manual will reduction in helping the analysis, remedy, and long term administration of autism, together with behavioral remedies, present scientific trials, and rising pharmaceutical remedies. Autism spectrum sickness (ASD) is a developmental affliction characterized by means of disturbance in language, conception, and social talents that is affecting an anticipated 1–2 according to 1,000 humans around the world (although the quantity is as excessive as 20 in step with one thousand within the US). whereas experiences have instructed a disturbance in neural metabolism in sufferers with advertisements, the precise reason for the ASD nonetheless is still unknown. In 2013, a unmarried indication of ASD, which united a number of comparable stipulations (ie, classical autism, Asperger’s syndrome, Fragile X Syndrome, Landau-Kleffner Syndrome, Rett syndrome, formative years disintegrative sickness, and PDD-NOS), was once incorporated within the 5th version of the Diagnostic and Statistical guide of temper problems for the 1st time so one can help extra standardized diagnoses.

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Additional info for Clinician’s Manual on Autism Spectrum Disorder

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Findings to date indicate that genetic contributions to autism are highly heterogeneous. More than 200 loci have been found to confer risk of ASD in different individuals, although each variation accounts for less than 1% of individuals with ASD. In addition, the phenotypic expression or penetrance of these genetic components is also highly variable. Studies have demonstrated a range from fully penetrant point mutations to polygenic forms with multiple gene-gene and geneenvironment interactions [22,23].

Conclusions Psychiatric comorbidity is common in ASD and must be part of the general assessment of affected individuals and considered when developing a treatment plan. Recent changes in the DSM-5 now facilitate the diagnosis of comorbid psychiatric conditions in ASD. However, there are very few validated tools to help support clinicians in assessing for comorbid disorders in this population. Therefore, clinicians must use psychiatric tools with caution when assessing for psychiatric comorbidity in ASD, and use their clinical judgment in combination with direct observation of the affected individual, careful history taking with parents/caregivers, 30 • CL IN I C I A N’S MA N UA L O N AU T IS M S P E C T RU M D IS O RD E R family, and collateral information obtained from other relevant informants (ie, teachers, therapists) to determine whether a comorbid psychiatric diagnosis should be made.

This has led to experimental models of ASD in genetically-modified knockout mice. M E D I C A L CO M O R B I D I T I E S I N AU T I S M S P E C T R U M D I S O R D E R • 35 Individuals with ASD may present with variety of seizure types including grand mal and petit mal. Partial complex seizures reportedly occur most often, but can be difficult to assess. This is because the movements seen in partial complex seizures can be confused with the repetitive and unusual motor behaviors often seen as part of the behavioral presentation of ASD.

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Clinician’s Manual on Autism Spectrum Disorder by Evdokia Anagnostou

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