By Timothy GK Mant, Lionel D Lewis, James M Ritter, Albert Ferro
So that you imagine you will have a deal with on healing administration? How medications paintings and have interaction with one another, how the physique handles them and the way drugs are assessed? This self-assessment quantity lets you study, revise and try out your self on all points of scientific pharmacology and therapeutics. 4 varied query varieties are supplied to check your wisdom during this very important zone - a number of selection questions, prolonged matching questions, better of fives and problem-solving questions. exact explanatory solutions be certain this booklet solves your queries in addition to supplying crucial revision for these all-important assessments. try your wisdom with medical Pharmacology and Therapeutics: Questions for Self review and never purely increase your examination process yet develop into a greater prescriber.
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Additional info for Clinical Pharmacology and THerapeutics: Questions for Self Assessment, 3rd edition
The onset of action is at least 48–72 hours after initiation of treatment following a loading dose. There is wide variability in drug response related to genetics, hepatic function, drug and alcohol interactions. Monitoring of treatment through measurement of INR (international normalized ratio) calculated from the prothrombin time is essential. Prolongation of INR predisposes to haemorrhage. 2 J Insulin controls the metabolic disposition of carbohydrate, fats and amino acids. Insulin is inactivated by gastrointestinal enzymes, hence administration is by injection or occasionally by inhalation.
1 I The absorption of gentamicin (and other aminoglycoside antibacterial drugs) following oral administration is minimal. Hence gentamicin is used by injection (intramuscular and intravenous) and topically. 2 B Amiodarone, an effective antidysrhythmic drug, is only slowly eliminated by the liver, with a mean elimination half-life of 53 days. Hence effects may continue for several months after dosing has ceased. 3 E Enalapril is hydrolysed to its active metabolite, enalaprilat, which is an ACE inhibitor.
Hence gentamicin is used by injection (intramuscular and intravenous) and topically. 2 B Amiodarone, an effective antidysrhythmic drug, is only slowly eliminated by the liver, with a mean elimination half-life of 53 days. Hence effects may continue for several months after dosing has ceased. 3 E Enalapril is hydrolysed to its active metabolite, enalaprilat, which is an ACE inhibitor. 4 C Carbamazepine, an antiepileptic, induces its own metabolism such that plasma concentrations reduce significantly on repeated dosing.
Clinical Pharmacology and THerapeutics: Questions for Self Assessment, 3rd edition by Timothy GK Mant, Lionel D Lewis, James M Ritter, Albert Ferro