Cardiovascular Plaque Rupture (Fundamental and Clinical by David Brown PDF

By David Brown

ISBN-10: 0203908910

ISBN-13: 9780203908914

ISBN-10: 082470276X

ISBN-13: 9780824702762

Illustrating the advance and determinants of attainable plaque rupture, Cardiovascular Plaque Rupture offers an in-depth overview of the pathology, etiology, mobile and molecular biology, analysis, and therapy of plaque within the cardiovascular system-exploring the jobs of actual rigidity, irritation, and infectious brokers at the progress of heart problems. represent and establish susceptible plaque utilizing novel imaging modalities and alterations of present invasive and noninvasive applied sciences! Containing contemporary facts on preventive gene treatment and antibiotic stabilization of plaque, >Cardiovascular Plaque Rupture considers ·serine proteinase and metalloproteinase inhibitors within the prevention of plaque rupture ·lipid decreasing to stabilize plaque ·clinical trial designs to illustrate healing prevention of plaque rupture ·and extra! Discussing present equipment of plaque evaluation, together with intravascular ultrasound and elastography, in vivo spectroscopic research, optical coherence tomography, thermography, and magnetic resonance imaging, Cardiovascular Plaque Rupture is an fundamental consultant for cardiologists, vascular and cardiac surgeons, radiologists, vascular biologists, endocrinologists, and fellows, citizens, and scientific institution scholars in those disciplines.

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Additional resources for Cardiovascular Plaque Rupture (Fundamental and Clinical Cardiology, 45)

Example text

Although interactions between extracellular matrix, growth factors, and cells are important, their relevance in plaque stability is not fully understood. Blood pressure changes have been proposed as a trigger for plaque rupture. For example, the cyclic pressure changes that an artery undergoes can lead to continuous stresses on a plaque (233). The correlation between blood pressure and tension is defined by LaPlace’s law, which states that tension in the vessel wall increases with increasing blood pressure and intraluminal diameter.

There are various isoforms of PDGF, PDGF-AA, PDGF-AB, and PDGF-BB, (caused by the two different polypeptide chains, A and B), along with different receptor types, PDGF-α-receptor and PDGF-β-receptor. SMC from injured arteries secrete only the PDGF-AA despite expressing the genes for both chains (184). Yet the receptor type that is expressed in these SMC is the βreceptor (185). It is uncertain why these cells would express one ligand and another type of receptor. The answer may be that different isoforms are generated for different functions with different target cells.

Although the stimulus for intimal hyperplasia can vary, the one common factor is damage to the endothelium and media of the artery. This injury triggers a complex series of events that Atherosclerotic Plaque Development 19 leads to a thickened intima. Endothelial dysfunction and denudation from the vessel wall has been implicated as the initial step in plaque formation (37, 82, 177). The result of this dysfunction or denuding is a compensatory response that alters the function of SMC and causes intimal thickening.

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Cardiovascular Plaque Rupture (Fundamental and Clinical Cardiology, 45) by David Brown

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