By P.A. Voûte, Ann Barrett, Michael C.G. Stevens, Hubert N. Caron
"Cancer in young ones" introduces paediatric oncology in a transparent and concise manner, overlaying the entire attainable problems that could come up in the course of therapy and a few of the results of the sickness. even supposing formative years melanoma is unusual, accounting for only 1% of all melanoma in industrialized nations, it really is one in every of nice clinical curiosity for a couple of purposes. various kinds of melanoma are nearly specified to youth, while the carcinomas most often visible in adults are super infrequent between childrens. the most impressive development in melanoma therapy has been made in paediatric oncology. research of adolescence tumours has ended in significant advances within the knowing of the genetic aetiology of melanoma. "Cancer in teenagers" brings jointly a global team of hugely revered editors and members who supply evidence-based details on how you can examine and deal with the typical cancers in early life. state-of-the-art descriptions of what's easy and crucial for administration are integrated; there are new chapters overlaying destiny tendencies in melanoma chemotherapy, surgical procedure, palliative care, myeloid leukaemia, and malignant mesenchymal tumours; new editors, and plenty of new members. geared toward paediatric oncologists, trainees in oncology and paediatrics, this e-book also will entice paediatric nurses, melanoma nurses, and paramedical paediatric employees.
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Extra resources for Cancer in Children: Clinical Management (Oxford Medical Publications)
4. Hartmann O (1995). New strategies for the application of high-dose chemotherapy with haematopoietic support in paediatric solid tumours. Ann Oncol 6 (Suppl 4), 13â 16. 5. Vassal G, Tranchand B, Valteau-Couanet D, et al. Pharmacodynamics of tandem high-dose melphalan with peripheral blood stem cell transplantation in children with neuroblastoma and medulloblastoma. Bone Marrow Transplant 27, 471â 7. 6. Reilly JJ, Workman P (1993). Normalisation of anti-cancer drug dosage using body weight and surface area: is it worthwhile?
If these DNA lesions are not repaired, the cell dies. The first alkylating agent to be used clinically was mechlorethamine, also known as nitrogen mustard. This drug was derived from the clinical observations of severe lymphopenia after the use of mustard gas in the First World War. Mechlorethamine is still being used for the treatment of Hodgkin lymphoma. Other alkylating agents that have a prominent role in paediatric oncology are cyclophosphamide, ifosfamide, melphalan, busulfan, thiotepa, and nitrosoureas such as carmustine (BCNU) and lomustine (CCNU).
Apoptosis of malignant cells without using the cytotoxic mechanisms summarized above can be achieved by the corticosteroids prednisone, prednisolone, and dexamethasone. They induce apoptosis in ALL cells after binding to the steroid receptors in the cellular membrane. The mechanism through which this leads to apoptosis is being investigated at present Cytotoxic and targeted drugs developed during the past decade, such as the taxanes (paclitaxel, docetaxel), the 36 37 topoisomerase I inhibitors (irinotecan, topotecan), temozolomide, and the new platinum compound oxaliplatin, have shown antitumour activity in several adult cancers.
Cancer in Children: Clinical Management (Oxford Medical Publications) by P.A. Voûte, Ann Barrett, Michael C.G. Stevens, Hubert N. Caron