By Hiroshi Shimizu, Takashi Hirasawa (auth.), Volker F. Wendisch (eds.)
Amino Acids Biosynthesis offers the present wisdom of basic in addition to utilized microbiology of amino acids. themes mentioned are the amino acid biosynthetic pathways, their genetic and biochemical legislation, delivery of amino acids and genomics of manufacturing microorganisms. The characterization of the regulate mechanisms of amino acid biosynthesis has published insights into rules of genetic and biochemical law, corresponding to transcriptional regulators and a brand new classification of regulatory components, the riboswitch.
The quantity extra offers with the metabolic engineering of microorganisms for the biotechnological construction of amino acids to be used as prescribed drugs and, rather, as nutrients and feed ingredients. entire reports are given of modern achievements to permit or increase construction of amino acids and dipeptides by means of fermentation and enzyme catalysis. right here, the actual concentration is on metabolic engineering, the rational development of metabolic services utilizing recombinant DNA technology.
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Additional info for Amino Acid Biosynthesis ~ Pathways, Regulation and Metabolic Engineering
A coupling method for enzymatic glutamine production by a bacterial GS reaction with energy transfer by baker’s yeast or a cell-free extract was also developed (Tachiki et al. 1981a,b, 1983; Wakisaka et al. 1998). 2 Proline In some bacteria, proline is synthesized in four reactions from glutamate via γ -glutamyl phosphate, γ -glutamic semialdehyde, and its spontaneous cyclization product ∆1 -pyrroline-5-carboxylate (Fig. 11). The enzymes involved in proline biosynthesis and their genes have been characterized.
Baich and Pierson (1965) reported that an E. coli mutant showing resistance to the proline analog 3,4-dehydroproline excreted proline into the culture medium. Nakamori et al. (1982) also reported that the 3,4-dehydroproline- and sulfaguanidine-resistant mutant strains of C. glutamicum produced high amounts of proline. Sano et al. (1987) reported that the proline productivity of dehydroproline-resistant strains of C. glutamicum was improved by overexpression of the phosphoenolpyruvate carboxylase gene to supply oxaloacetate.
58 58 60 References . . . . . . . . . . . . . . . . . . . . 62 . . . . . . . . . . . . . . Abstract l-lysine is an essential amino acid required for nutrition of animals and humans. It has to be present in food and feed, which, in many cases, is realized by supplementation of the feed-stuffs with pure lysine. The high importance of lysine in nutrition has stimulated intensive research on the lysine biosynthetic pathways and their regulation and the search for microorganisms capable of over-producing this amino acid.
Amino Acid Biosynthesis ~ Pathways, Regulation and Metabolic Engineering by Hiroshi Shimizu, Takashi Hirasawa (auth.), Volker F. Wendisch (eds.)