By Robert O. Williams III, David R. Taft, Jason T. McConville
This identify demonstrates how complicated formula designs and supply applied sciences can be utilized to enhance drug efficacy and therapy results particularly healing different types or affliction states. It discusses nanoparticle structures for melanoma remedies, and likewise offers leading edge immono-regulation brokers for transplantation and the neighborhood focusing on of substances, specially poorly water soluble medications to supply more desirable healing results. additionally, this identify highlights parts of remedy displaying the main promise for development in scientific results through complicated formula layout.
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Extra info for Advanced Drug Formulation Design to Optimize Therapeutic Outcomes (Drugs and the Pharmaceutical Sciences)
For a more in-depth review and discussion of conventional passive DPI systems, the reader is referred to recent reviews (11,83). Perhaps one of the most interesting applications of DPI technologies is the delivery of high molecular mass materials, such as proteins, to the body, offering systemic drug delivery. One such recent development is Inhale’s pulmonary Exubera system. In addition to being an active device, the product allows the delivery of insulin to the lung via a respirable mixture of excipients and insulin.
The molecules in these materials reduce particulate interactions by accumulating at the interface of the colloidal particles and act to either reduce interfacial tension, produce steric hindrance between particulates, or form colloid bridges to increase flocculation. An example of the influence of polymeric additives, such as polyethelene glycol (PEG) on drug cohesive forces is represented in Figure 14. As can be seen from Figure 14, particle cohesion in this model system is dependent on both the concentration and the molecular weight of the polymer used (99).
Furthermore, inspiratory flow rate can influence the dose emitted from an inhaler, the amount inhaled, the oropharyngeal deposition, and the regional lung deposition of inhaled medications (115). Consequently, the effective use of conventional pMDIs, as shown in Figure 17, is technique dependent (116,117). In the late 1960s, development began on the first breath-actuated inhaler. Having seen the difficulty that some patients experienced when coordinating pressing and breathing, an opportunity was identified for a device that would actuate as the patient breathed in.
Advanced Drug Formulation Design to Optimize Therapeutic Outcomes (Drugs and the Pharmaceutical Sciences) by Robert O. Williams III, David R. Taft, Jason T. McConville