A Textbook of Clinical Pharmacology and Therapeutics, 5th - download pdf or read online

By James M Ritter, Lionel D Lewis, Timothy GK Mant, Albert Ferro

ISBN-10: 0340900466

ISBN-13: 9780340900468

If you happen to know how medications paintings (pharmacodynamics), how they're dealt with through the physique (pharmacokinetics), how they have interaction with one another, and the way medicines are assessed, then you definately becomes a greater prescriber. A Textbook of scientific Pharmacology and Therapeutics provides that knowing. absolutely revised all through and broadly illustrated, the 5th variation of this well-established textbook has been streamlined to target what clinical scholars and junior medical professionals actually need to understand with the intention to comprehend the results of prescribing one drug over, or together with, one other. The textual content offers present details on all parts of drug prescribing with up-to-date dialogue and assistance on such themes as hostile drug reactions, custom-made drugs, gene and cell-based remedy, advances in melanoma remedy, and mechanisms of drug motion and remedy guidance in HIV and mycobacterial infections treatment. a brand new bankruptcy on substitute medications and nutraceuticals has been brought and extra examining lists were up-to-date to incorporate key clinical web pages. All clinical scholars and junior medical professionals who learn this publication will examine not just easy methods to use medications thoroughly and successfully, yet, importantly, the reason in the back of powerful prescribing judgements.

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Extra info for A Textbook of Clinical Pharmacology and Therapeutics, 5th edition

Sample text

OXIDATION Microsomal oxidation causes aromatic or aliphatic hydroxylation, deamination, dealkylation or S-oxidation. g. flavin-containing monooxygenases or epoxide hydrolases). CYP450s exist in several distinct isoenzyme families and subfamilies with different levels of amino acid homology. Each CYP subfamily has a different, albeit often overlapping, pattern of substrate specificities. 1. CYP450 enzymes are also involved in the oxidative biosynthesis of mediators or other biochemically important intermediates.

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Annual Review of Pharmacology and Toxicology 2001; 41: 535–67. Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. Pharmacogenetics 2004; 14: 1–18. edu/flockhart/table, accessed April 2007. 1). The contribution of renal excretion to total body clearance of any particular drug is 1 Free drug enters glomerular filtrate ● ● Passive distal tubular reabsorption Active tubular reabsorption 32 33 determined by its lipid solubility (and hence its polarity).

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A Textbook of Clinical Pharmacology and Therapeutics, 5th edition by James M Ritter, Lionel D Lewis, Timothy GK Mant, Albert Ferro


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